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Organ-on-chip: advancing nutraceutical testing for improved health outcomes

A metabolomic screen of an orthotopic xenograft model of TRAMP-C1 prostate cancer demonstrated increased glycolysis in tumors following androgen deprivation ( in vivo and ex vivo metabolic imaging using hyperpolarized 1-[ 13 C]pyruvate in TRAMP tumors also points towards elevated glycolysis and higher lactate dehydrogenase (LDH) activity in the castrate setting ( Evidence from human studies similarly show different glucose utilization across the spectrum of prostate cancer, which is best illustrated by 18 F-fluorodeoxyglucose ( 18 F-FDG) cancer diagnostic imaging in patients

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On the other hand, protective bacterial species, such as Bifidobacterium, Lactobacillus and Butyricicoccus, that promote a healthy gut barrier and enhance immune tolerance, are reduced in patients with HT [182]

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